UTHThe University of Texas Health Science Center at Houston · Neuroscience
Microglial Response and Stroke Lab
Gab Seok Kim · Houston, Texas
Research Focus
Dr. Gab Seok Kim's research lab focuses on understanding how microglia, the brain's immune cells, respond to strokes, particularly in older adults. The lab investigates a specific gene called Ifi27l2a that may heighten inflammation in the brain after a stroke, examining its role in both worsening brain injury and potential recovery. Through various experimental approaches, they aim to discover how manipulating this gene could lead to better treatment strategies for stroke and related neurodegenerative diseases.
microgliastrokeinflammationgene regulationbrain injuryage-related neurodegenerationtherapeutic targetsneuroinflammationblood-brain barrier
Research Aims
4AIM 01Investigate the role of Ifi27l2a in microglial inflammation following stroke.
AIM 02Define the functional implications of Ifi27l2a regulation in aged microglia.
AIM 03Explore the relationship between Ifi27l2a expression and blood-brain barrier integrity.
AIM 04Test therapeutic strategies to reduce Ifi27l2a expression in stroke models.
Skills the Lab Values
single-cell transcriptomic analysis (scRNA-seq)in vivo mouse modelsin vitro cell culturegene expression analysisbulk RNA sequencingimmunohistochemistryflow cytometryprotein assayswestern blotting
Output against the department
Publications53bottom 12% of dept.587th of 671
this lab
most publishedleast published
Citations3.0kbottom 22% of dept.526th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.