University of North Carolina at Chapel Hill · PhysiologyPhilpot Retinal Lab
Benjamin D Philpot · Chapel Hill, North Carolina
Research Focus
Dr. Benjamin Philpot's lab at the University of North Carolina focuses on developing innovative treatments for retinal degeneration and Angelman syndrome. They are utilizing advanced models, such as mouse models and retinal organoids, to explore gene therapies and small molecule drugs aimed at boosting visual function and reversing neurodevelopmental disorders. The lab's research aims to transform the lives of patients suffering from these challenging conditions.
gene therapyretinal degenerationsmall molecule therapeuticsAngelman syndromeretinal organoidsmouse modelsneuroscienceepigeneticsphotoreceptorsdisease modeling
Research Aims
4AIM 01Leverage mouse models and retinal organoids to develop a gene therapy for retinal degeneration.
AIM 02Assess the safety and efficacy of gene therapy in preclinical models.
AIM 03Investigate small molecules to unsilence UBE3A for treating Angelman syndrome.
AIM 04Evaluate behavioral and electrophysiological improvements in Angelman syndrome mouse models.
Skills the Lab Values
gene editingmouse model experimentationretinal organoid cultureAAV-mediated gene transferbehavioral assayspharmacology screeningPCRWestern blotelectrophysiologyimmunohistochemistry
Output against the department
Publications175top 39% of dept.111th of 286
this lab
most publishedleast published
Citations10ktop 31% of dept.90th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.