University of Michigan-Ann Arbor · BiologyInflammation and Alzheimer's Research Lab
Richard F Keep · Ann Arbor, Michigan
Research Focus
Dr. Richard F Keep's lab focuses on understanding how inflammation in the brain contributes to Alzheimer's disease. They are investigating the role of a specific protein, junctional adhesion molecule-A (JAM-A), in attracting immune cells called neutrophils to the brain, which may harm brain function. By studying these processes, the lab aims to uncover new therapeutic approaches to slow down cognitive decline in Alzheimer's patients.
Alzheimer's diseaseneuroinflammationjunctional adhesion molecule-Aneutrophilsinflammatory responsecognitive impairmenttherapeutic strategiesneutrophil extracellular trapsblood-brain barrier
Research Aims
4AIM 01Investigate how JAM-A influences neutrophil recruitment in Alzheimer's disease.
AIM 02Determine the effects of a JAM-A knockout on neutrophil accumulation in the brain.
AIM 03Evaluate the molecular mechanisms behind JAM-A's role in inflammation.
AIM 04Assess the impact of JAM-A antagonist peptides on neuroinflammation and cognitive deficits.
Skills the Lab Values
mouse modelsgene knockout techniquescell cultureimmunohistochemistryflow cytometryWestern blot analysisbehavioral assayspeptide designinflammation assays
Output against the department
Publications539top 7% of dept.69th of 1,033
this lab
most publishedleast published
Citations33ktop 10% of dept.101st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.