Columbia University in the City of New York · PhysiologyMancia Structural Lab
Filippo Mancia · New York, New York
Research Focus
The research lab led by Filippo Mancia at Columbia University focuses on understanding the molecular mechanisms of drug resistance in malaria and the transport of signaling molecules known as Wnts. By employing advanced techniques such as cryo-electron microscopy, gene editing, and imaging, the lab explores how specific proteins interact with drugs and each other, aiming to develop better treatments for malaria and uncover the factors that influence cell signaling. Their work combines structural biology, computational modeling, and biochemical assays to shed light on these critical processes.
malariadrug resistancePfCRTWnt signalingstructural biologymachine learninggene editingproteinscell signalingbiophysical methods
Research Aims
4AIM 01Characterize the structural basis of PfCRT-mediated drug resistance.
AIM 02Investigate the transport mechanisms of Wnt proteins by WLS.
AIM 03Analyze genetic variations in pfcrt that arise due to local drug pressures.
AIM 04Develop predictive models for drug resistance mutations using machine learning techniques.
Skills the Lab Values
cryo-electron microscopygene editingprotein structure determinationbiochemical assaysreal-time imagingmolecular dynamics simulationscell culturemutagenesis techniquesdata analysis in biologycomputational modeling
Output against the department
Publications149bottom 49% of dept.145th of 286
this lab
most publishedleast published
Citations4.4kbottom 37% of dept.181st of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.