Tufts University · BiologyShigella Pathogenesis Research Lab
Cammie Lesser · Medford, Massachusetts
Research Focus
Cammie Lesser's lab at Tufts University focuses on understanding how the bacterium Shigella survives and replicates inside human intestinal cells. By studying how Shigella manipulates the immune system, particularly through inflammatory cell death processes, the lab aims to uncover new strategies for preventing and treating severe infections caused by this pathogen. This research is vital, especially in light of rising antibiotic resistance.
Shigellainflammasomesintestinal epithelial cellspyroptosisantibiotic resistanceimmune evasiontype III secretion systemcell deathinflammationpathogenesis
Research Aims
5AIM 01Investigate how Shigella effectors inhibit pyroptosis in intestinal epithelial cells.
AIM 02Explore the mechanisms of immune evasion by Shigella in the gut environment.
AIM 03Study the interactions between Shigella and host cell processes at the molecular level.
AIM 04Develop new host-targeted strategies for preventing Shigella infections.
AIM 05Understand the role of inflammasomes in Shigella pathogenesis.
Skills the Lab Values
Cell cultureMolecular cloningPCRWestern blotMicroscopyFlow cytometryRNA sequencingAnimal modelsBacterial cultureProtein purification
Output against the department
Publications84bottom 26% of dept.757th of 1,033
this lab
most publishedleast published
Citations3.8kbottom 29% of dept.731st of 1,033
this lab
most citedleast cited
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