University of Maryland, Baltimore · PharmacologyAntalis Lab
Toni M Antalis · Baltimore, Maryland
Research Focus
Dr. Toni M. Antalis leads a research lab focused on understanding how blood vessels form and repair themselves, particularly in the context of cardiovascular diseases. The lab investigates the mechanisms that govern the resolution of angiogenesis, which is crucial for healing and normalizing blood flow. By studying how a specific protein called testisin affects blood vessel development, the lab aims to discover new treatments for conditions that arise from poor or excessive blood vessel formation, such as heart disease and cancer.
angiogenesisvascular repaircardiovascular diseasestestisinvascular normalizationmicrovascular integritytumor vasculatureischemiawound healing
Research Aims
5AIM 01Define mechanisms by which testisin deficiency impairs resolution of angiogenesis.
AIM 02Test the therapeutic efficacy of augmenting the testisin pathway to promote resolution of angiogenesis.
AIM 03Investigate the role of endothelial cells in vascular remodeling during angiogenesis.
AIM 04Explore the relationship between vascular integrity and disease progression.
AIM 05Develop strategies for enhancing therapeutic angiogenesis.
Skills the Lab Values
molecular biologybiochemistrycell culturemouse modelsgene deliveryproteomicstissue imagingWestern blotin vitro assays
Output against the department
Publications149bottom 42% of dept.268th of 462
this lab
most publishedleast published
Citations7.4ktop 49% of dept.225th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.