University of Rochester · Biomedical EngineeringAngiotensin Care Lab
Brian Marples · Rochester, New York
Research Focus
Dr. Brian Marples leads a research lab at the University of Rochester focusing on the prevention of bladder injuries in cancer patients undergoing pelvic radiotherapy. The lab investigates how modulation of the renin-angiotensin system can reduce inflammation and toxicity caused by radiation, aiming to develop urine-based biomarkers that predict bladder injury. Ultimately, the goal is to minimize the painful side effects of treatment and improve the quality of life for patients.
radiotherapybladder injuryangiotensinbiomarkersinflammationcystitiscancer treatmentpreventiontoxicityclinical trials
Research Aims
4AIM 01Characterize mechanisms of bladder inflammation and immune cell recruitment after radiation therapy.
AIM 02Determine optimal duration of angiotensin inhibitors for preventing bladder injury during radiation treatment.
AIM 03Assess urinary extracellular vesicle release as a predictive biomarker of radiation-induced injury.
AIM 04Validate urinary biomarkers in clinical studies to identify patients needing early intervention for bladder injury.
Skills the Lab Values
cell culturemouse modelsflow cytometrybiomarker developmentgenetic analysisclinical study designnanoparticle trackingdata analysisimmunohistochemistrySNP genotyping
Output against the department
Publications321top 29% of dept.173rd of 595
this lab
most publishedleast published
Citations6.7ktop 50% of dept.297th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.