University of Oregon · NeuroscienceNeural Circuit Dysfunction Lab
Michael Wehr · Eugene, Oregon
Research Focus
Michael Wehr's lab at the University of Oregon focuses on understanding how neural circuit disruptions lead to cognitive declines in Alzheimer's disease. By examining the relationship between auditory gap detection deficits and large-scale network dysfunctions in the brain, the lab aims to uncover the mechanisms behind specific behavioral impairments. Their research combines advanced imaging and electrophysiology techniques in mouse models to explore potential biomarkers for early Alzheimer's diagnosis and to inform therapeutic interventions.
Alzheimer's diseaseneural circuitsauditory processingbiomarkerscognitive decline
Research Aims
3AIM 01Investigate the mechanisms of network disruption in auditory circuits associated with Alzheimer's.
AIM 02Examine how feedforward and feedback information flow is altered in cortical networks.
AIM 03Understand the impact of network disruption on auditory gap detection behavior.
Skills the Lab Values
chronic mesoscopic imaging2-photon microscopyelectrophysiologybehavioral testingdata analysis
Output against the department
Publications68bottom 18% of dept.544th of 671
this lab
most publishedleast published
Citations5.5kbottom 39% of dept.407th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.