Yale University · BiochemistryCrews Degradation Lab
Craig M Crews · New Haven, Connecticut
Research Focus
Dr. Craig M. Crews leads a research lab at Yale University focused on innovative methods to treat diseases like Sickle Cell Disease (SCD) and certain cancers. His team explores new drugs that can degrade problematic proteins that contribute to these diseases, making it easier to target challenging medical conditions. By developing small molecules that induce the degradation of specific proteins, they aim to improve treatment effectiveness and create more targeted therapies.
Sickle Cell Diseaseprotein degradationoncologyPROTACstargeted therapytherapeutic modalitiesfetal hemoglobincontrolled proteostasis
Research Aims
5AIM 01Develop targeted protein degraders to increase fetal hemoglobin levels for treating Sickle Cell Disease.
AIM 02Innovate drug development methods for degrading undruggable cancer proteins.
AIM 03Identify key oncogenic proteins for targeted degradation using PROTACs.
AIM 04Translate laboratory research into clinical applications for cancer therapies.
AIM 05Expand the range of protein classes that can be pharmacologically targeted.
Skills the Lab Values
CRISPRcell cultureprotein assaysflow cytometryhigh pressure liquid chromatographyDNA sequencinganimal modelsdrug designbiological assaysMolecular Biology Techniques
Output against the department
Publications317top 20% of dept.79th of 402
this lab
most publishedleast published
Citations44ktop 6% of dept.23rd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.