Harvard University · Microbiology & ImmunologyThe Antibody Initiative
Roger L Shapiro · Cambridge, Massachusetts
Research Focus
Dr. Roger L. Shapiro's lab at Harvard focuses on improving treatment strategies for children and pregnant women living with HIV. Their research emphasizes the use of broadly neutralizing antibodies as potential alternatives to traditional antiretroviral therapy (ART), with aims to enhance safety and effectiveness during sensitive developmental periods. The lab conducts clinical trials in Botswana to explore innovative approaches, including the safe interruption of ART, and addresses critical questions concerning treatment during pregnancy and infancy.
HIVbroadly neutralizing antibodiespediatric HIV treatmentantiretroviral therapyclinical trialsBotswanamother-infant healthviral reservoirtreatment interruptionprecision medicine
Research Aims
4AIM 01Investigate the safety and pharmacokinetics of broadly neutralizing antibodies in children living with HIV.
AIM 02Determine the effectiveness of ART interruption in selected pediatric populations.
AIM 03Evaluate the impact of ART strategies on maternal and infant outcomes during pregnancy.
AIM 04Develop and validate new methodologies for ART regimen studies in pregnancy.
Skills the Lab Values
clinical trial designimmune response assessmentpharmacokineticsbiostatisticsHIV testing techniquesdata analysisin vitro assayspatient monitoringbiological sample collectionmolecular biology techniques
Output against the department
Publications284top 18% of dept.88th of 486
this lab
most publishedleast published
Citations13ktop 29% of dept.139th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.