University of Washington-Seattle Campus · ChemistryGelb Lab
Michael H Gelb · Seattle, Washington
Research Focus
Dr. Michael H Gelb's lab at the University of Washington focuses on improving newborn screening for genetic diseases using advanced biochemical and molecular techniques. Their research aims to develop innovative methods to analyze DNA variants and protein mutations that could influence disease outcomes. This work could significantly enhance how newborns are screened for treatable conditions, leading to better health strategies and reduced anxiety for families.
newborn screeningwhole genome sequencingbiochemical annotationmass spectrometryDNA variantsprotein foldingdiagnostic techniquescongenital diseasestandem mass spectrometryfluorescence-activated cell sorting
Research Aims
5AIM 01Develop new techniques to annotate variants of unknown significance in proteins.
AIM 02Create assays for newborn screening of congenital diseases.
AIM 03Optimize methods for reducing false positives in newborn screening tests.
AIM 04Investigate the relationship between protein function levels and disease severity.
AIM 05Implement mass spectrometry for enhanced diagnostic accuracy in newborns.
Skills the Lab Values
mass spectrometryDNA library preparationprotein engineeringcell transfectionfluorescence microscopytandem mass spectrometrynext-generation sequencingbiochemical assayscell cultureRNA barcoding
Output against the department
Publications824top 6% of dept.13th of 216
this lab
most publishedleast published
Citations43ktop 7% of dept.16th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.