University of Pennsylvania · BiologyAcute Myeloid Leukemia Immunotherapy Lab
Xianxin Hua · Philadelphia, Pennsylvania
Research Focus
Xianxin Hua's research lab at the University of Pennsylvania focuses on developing innovative immunotherapies for treating acute myeloid leukemia (AML). The lab is particularly interested in creating CAR T cells that target specific proteins on AML cells to improve treatment effectiveness while minimizing damage to healthy cells. Their work aims to translate new findings into clinical applications to offer better therapeutic options for patients with refractory AML.
acute myeloid leukemiaCAR T cellsimmunotherapybispecific CAR Tnanobodieschemo-resistanceleukemia stem cellsanimal models
Research Aims
3AIM 01Evaluate the efficacy of bispecific CD13/TIM-3 CAR T cells in targeting AML cells.
AIM 02Investigate the specificity and effectiveness of inducible CAR T cells against AML.
AIM 03Develop innovative bispecific therapies for selective targeting of leukemia cells.
Skills the Lab Values
cell cultureanimal modelsflow cytometryWestern blotgene editingimmunofluorescenceprotein purificationPCR
Output against the department
Publications151top 45% of dept.461st of 1,033
this lab
most publishedleast published
Citations11ktop 34% of dept.347th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.