UMCUniversity of Massachusetts Chan Medical School · Genetics
Chromosome Dynamics Lab
Job Dekker · Worcester, Massachusetts
Research Focus
The research lab of Job Dekker at the University of Massachusetts Medical School focuses on understanding how the human genome is organized and regulated. His team investigates how the three-dimensional structure of chromosomes affects gene expression and stability, and how defects in this organization can lead to diseases such as cancer. By employing cutting-edge genomic technologies, they explore the molecular mechanisms that facilitate proper chromosome folding and segregation during the cell cycle.
chromosome foldinggene expressiongenome stabilitychromosome segregationgenomic technologiescatenationcis elementstopologically associating domainscohesincondensin
Research Aims
5AIM 01Investigate the identity of cis elements that mediate sister chromatid interactions.
AIM 02Explore the topological state of chromosomes and the role of catenation.
AIM 03Characterize factors that drive chromosome compartmentalization.
AIM 04Develop genomic technologies to study chromosome behavior during the cell cycle.
AIM 05Identify genetic elements that control chromosome folding and segregation.
Skills the Lab Values
Hi-C techniqueschromosome imaginggene expression analysisgenome editingPCRcell culturebioinformaticsliquid chromatographydata visualizationstatistical analysis
Output against the department
Publications392top 18% of dept.47th of 259
this lab
most publishedleast published
Citations73ktop 9% of dept.23rd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.