UMCUniversity of Massachusetts Chan Medical School · Genetics
Pai RNA Lab
Athma A Pai · Worcester, Massachusetts
Research Focus
Dr. Athma A. Pai's lab at the University of Massachusetts Medical School focuses on understanding how genes control the production of different RNA molecules from the same gene. They use advanced techniques to measure how quickly RNA is made and processed, which helps to explain the variety of RNA molecules found in different cells. This research is important for uncovering how genetic differences can affect human health and disease.
RNA processingalternative splicinggenetic variantsmRNA biogenesisRNA-sequencingkinetic modelinggenotype-phenotype correlationquantitative trait locimolecular coordination
Research Aims
3AIM 01Develop a statistical model to estimate RNA processing rates at individual sites.
AIM 02Characterize kinetic competition between events that affect alternative isoform expression.
AIM 03Estimate RNA processing rates in populations of human cells to identify quantitative trait loci associated with variability in processing rates.
Skills the Lab Values
RNA sequencingstatistical modelingbioinformaticsexperimental designmolecular biology techniquesdata analysistime-series analysisgenetic mappingKinetic analysis
Output against the department
Publications74bottom 20% of dept.204th of 259
this lab
most publishedleast published
Citations8.7kbottom 46% of dept.140th of 259
this lab
most citedleast cited
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