Duke University · Biomedical EngineeringGersbach Immunotherapy Lab
Charles A. Gersbach · Durham, North Carolina
Research Focus
Dr. Charles A. Gersbach's lab at Duke University focuses on harnessing the immune system to enhance cancer treatments, particularly through adoptive T cell therapy. They use cutting-edge techniques to understand how to improve T cell function by manipulating specific genes and regulatory elements. The lab aims to make advancements in epigenetic engineering to create more effective cancer therapies and to systematically study gene regulatory elements that can impact diverse biological processes.
T cell therapyepigenetic programminggene regulatory elementsCRISPRcancer immunotherapyhigh-throughput screeningtranscriptomic profilingcellular phenotypes
Research Aims
5AIM 01Enhance T cell functionality for better cancer therapy outcomes
AIM 02Identify critical epigenetic targets for T cell programming
AIM 03Systematically characterize gene regulatory elements in human cells
AIM 04 Develop technologies to manipulate gene regulation in vivo
AIM 05Share methods and data with the scientific community to advance research.
Skills the Lab Values
CRISPRepigenome editingcell culturesingle-cell RNA sequencinganimal modelshigh-throughput screeninggene annotationdata analysismicroscopy
Output against the department
Publications243top 42% of dept.248th of 595
this lab
most publishedleast published
Citations23ktop 14% of dept.85th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.