Northwestern University · NeuroscienceThe NeuroGenesis Lab
Dimitri Krainc · Evanston, Illinois
Research Focus
Dr. Dimitri Krainc's lab at Northwestern University focuses on understanding the mechanisms behind Parkinson's disease using patient-derived cells. They study how different genetic factors influence the health of dopamine neurons and the role of surrounding glial cells, such as microglia and astrocytes, in neurodegeneration. The lab employs cutting-edge techniques to explore the interactions between cellular pathways and develop new experimental models for studying various aspects of Parkinson's and other neurodegenerative diseases.
Parkinson's Diseasedopaminergic neuronsmicrogliaastrocytesGBA1-PDinduced pluripotent stem cellsneurodegenerationgenetic modifierscell cultureinnovative technology
Research Aims
5AIM 01Investigate the role of genetic modifiers in Parkinson's disease using patient-derived neurons.
AIM 02Examine the protective and harmful roles of glial cells in neurodegeneration.
AIM 03Utilize innovative technology to analyze large numbers of genetic variants in a pooled approach.
AIM 04Explore the dynamics between lysosomes and mitochondria in dopamine neurons.
AIM 05Develop new experimental approaches for broader studies in neurodegeneration.
Skills the Lab Values
induced pluripotent stem cell cultureco-culture techniquescellular assaysgenetic analysismicroscopyWestern blottingRNA sequencingflow cytometryneuron differentiationdata analysis
Output against the department
Publications208top 35% of dept.237th of 671
this lab
most publishedleast published
Citations25ktop 16% of dept.108th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.