University of California-Davis · Biomedical EngineeringB Cell Dynamics Lab
Steven Carl George · Davis, California
Research Focus
Dr. Steven Carl George's lab focuses on innovative research aimed at enhancing our understanding of the immune response, particularly in relation to B cells and their functionality against infections like influenza and SARS-CoV-2. They are developing a new microfluidic technology to measure how effectively these B cells can bind to viruses, which could inform vaccine development and improve therapeutic strategies. This work combines engineering and biology to create tools that assess immune health and response.
B cell responsesinfluenzamicrofluidic technologyimmune assessmentvaccine development
Research Aims
5AIM 01Develop a microfluidic device to capture and separate B cells based on their binding avidity.
AIM 02Characterize how B cell binding dynamics relate to immune status after influenza infection.
AIM 03Assess the functionality of memory B cells in response to mutated pathogens.
AIM 04Create an adaptable technology for evaluating antibody responses to various antigens.
AIM 05Provide a rapid system for analyzing the functional capacity of B cells for vaccine improvement.
Skills the Lab Values
microfluidic device designflow cytometryB cell separation techniquesantigen affinity measurementcell cultureenzyme-linked immunosorbent assay (ELISA)data analysis using Pythonexperimental designimmunological assays