RUThe Rockefeller University · Genetics
Brady Lab
Sean F Brady · New York, New York
Research Focus
Dr. Sean F. Brady's lab at Rockefeller University focuses on discovering new antibiotics from soil microbiomes using advanced metagenomic techniques. By extracting DNA directly from environmental samples, they bypass the need to culture bacteria, enabling the identification of a vast array of novel natural products. These new compounds may serve as lead structures for the development of effective therapies against drug-resistant bacterial pathogens.
antibioticsmetagenomicsnatural productsbacterial diversitydrug discovery
Research Aims
4AIM 01Explore the genetic diversity of soil microbiomes to find antibiotic-producing bacteria.
AIM 02Develop new methods for the high-throughput discovery of natural products.
AIM 03Characterize novel bioactive small molecules from metagenomic data.
AIM 04Identify starting points for the development of new therapeutics against multi-drug resistant bacteria.
Skills the Lab Values
metagenomic sequencingDNA extractioncloning techniquessynthetic biologybioinformaticshigh-throughput screeningculture-independent methodsfunctional screeningdata analysis
Output against the department
Publications200top 42% of dept.109th of 259
this lab
most publishedleast published
Citations15ktop 39% of dept.102nd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.