Johns Hopkins University · Microbiology & ImmunologyDimopoulos Immunology Lab
George Dimopoulos · Baltimore, Maryland
Research Focus
George Dimopoulos's research lab at Johns Hopkins University focuses on understanding how Aedes aegypti mosquitoes respond to infections by arboviruses like Dengue and Zika. By exploring the immune mechanisms within these mosquitoes, especially through RNA interference and traditional immune pathways, the goal is to develop innovative strategies to reduce the spread of these diseases. This research is particularly important for public health as it can lead to new ways to control mosquito populations and limit virus transmission.
Aedes aegyptiarbovirusesRNA interferenceimmune pathwaysgenetic controlZika virusDengue virusviral transmissionimmunityvector biology
Research Aims
4AIM 01Investigate the role of the siRNA pathway in antiviral defense in Aedes aegypti.
AIM 02Elucidate the mechanisms behind immune tolerance to viral infections in mosquitoes.
AIM 03Explore the interactions between antiviral and antimicrobial immunity pathways.
AIM 04Develop genetic strategies to enhance mosquito resistance against arboviruses.
Skills the Lab Values
RNA sequencingCRISPR gene editingcell culturemicroscopygene activation techniquesproteomicsdata analysisvector designmicrobial assayspathogen interaction studies
Output against the department
Publications305top 16% of dept.76th of 486
this lab
most publishedleast published
Citations24ktop 16% of dept.76th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.