Thomas Jefferson University · NeuroscienceNervous System Pain Research Lab
Angelo C. Lepore · Philadelphia, Pennsylvania
Research Focus
Dr. Angelo C. Lepore's lab at Thomas Jefferson University focuses on understanding how certain proteins in the nervous system influence pain after spinal cord injuries. Using advanced genetic mouse models, the lab investigates how the EphB2 receptor interacts with NMDA receptors to affect nerve signaling and contribute to chronic pain conditions. The ultimate goal is to discover new ways to manage pain without relying on traditional opioid treatments.
neuropathic painspinal cord injuryEphB2 receptorNMDA receptorschronic painsynaptic transmissionpain circuitry
Research Aims
3AIM 01Examine the role of EphB2 receptor in neuropathic pain signaling pathways.
AIM 02Investigate how EphB2-NMDA receptor interactions affect synaptic localization and neurotransmission.
AIM 03Evaluate the effects of knocking out EphB2 on pain-related behaviors in spinal cord injury models.
Skills the Lab Values
mouse modelsgenetic manipulationbehavioral assaysphosphorylation studiesin vitro techniquesmolecular biology techniqueschemogeneticsimmunohistochemistry
Output against the department
Publications113bottom 40% of dept.403rd of 671
this lab
most publishedleast published
Citations4.6kbottom 34% of dept.445th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.