UCUniversity of Cincinnati-Main Campus · Biology
Cardiac Molecular Regulation Lab
Yigang Wang · Cincinnati, Ohio
Research Focus
Dr. Yigang Wang's lab focuses on understanding heart failure, a serious condition affecting millions globally. They explore how specific molecules, called miRNAs, impact heart cells and contribute to heart disease. By studying the mechanisms behind these processes, the lab aims to develop innovative therapies to mitigate heart failure and improve patient outcomes.
heart failuremiRNAcardiomyocytesepigeneticsmitochondriacardiac remodelingtherapeuticshypertrophygene regulation
Research Aims
3AIM 01Investigate the role of miR-128 in cardiac hypertrophy.
AIM 02Understand how miR-128 affects mitochondrial function in heart cells.
AIM 03Explore epigenetic mechanisms regulating miR-128 during heart failure.
Skills the Lab Values
RNA sequencingcell culturemouse modelsmolecular cloningepigenetic editingmass spectrometryWestern blotaffinity pull-downfunctional genomics
Output against the department
Publications326top 16% of dept.166th of 1,033
this lab
most publishedleast published
Citations9.6ktop 40% of dept.409th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.