Washington University in St Louis · NeuroscienceHoltzman Lab
David M. Holtzman · Saint Louis, Missouri
Research Focus
David M. Holtzman’s lab at Washington University focuses on understanding the mechanisms underlying neurodegeneration in Alzheimer's disease, particularly how T cells, microglia, and the APOE gene interact to exacerbate tau-related neurodegeneration. Researchers in this lab investigate both innate and adaptive immune responses in the brain and their contributions to the pathology of tau aggregation and neurodegeneration. The goal is to find new therapeutic targets that can slow or prevent the progression of Alzheimer's disease and related disorders.
Alzheimer's DiseasetauopathiesT cellsAPOE genotypemicroglianeurodegenerationimmune responseamyloid pathologyCNS pathology
Research Aims
3AIM 01Investigate the mechanisms of T cell activation in tau-mediated neurodegeneration.
AIM 02Examine antigen T cell receptor interactions relevant to tau pathology.
AIM 03Evaluate the impact of immunosuppressant drugs on tau-mediated neurodegeneration.
Skills the Lab Values
mouse modelsimmunological profilingflow cytometryT cell activation assaysmicroglial cultureWestern blottingRNA sequencinghistological analysisdata analysis with R/Python
Output against the department
Publications1,025top 3% of dept.20th of 671
this lab
most publishedleast published
Citations170ktop 1% of dept.5th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.