Yale University · Microbiology & ImmunologyLucas Lab
Carrie L. Lucas · New Haven, Connecticut
Research Focus
Dr. Carrie L. Lucas' lab at Yale University focuses on understanding how certain immune cells produce antibodies to fight infections. By studying a specific enzyme called PI3K-gamma, the lab investigates its role in B cells, the cells responsible for antibody production. The research efforts aim to uncover how defects in this pathway can lead to severe immune problems and explore potential new treatments for related diseases.
antibody responseB cell differentiationPI3K-gammaimmunologyautoimmunity
Research Aims
3AIM 01Investigate the downstream effects of PI3K-gamma on B cell processes
AIM 02Identify molecular signals that influence B cell differentiation into antibody-secreting cells
AIM 03Test how changing PI3K-gamma activity affects antibody responses in models of disease.
Skills the Lab Values
mouse modelsB cell cultureflow cytometryWestern blotRNA sequencing
Output against the department
Publications247top 23% of dept.113th of 486
this lab
most publishedleast published
Citations14ktop 28% of dept.136th of 486
this lab
most citedleast cited
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