Michigan State University · BiochemistryLiver Health and Contaminant Research Unit
Timothy R. Zacharewski · East Lansing, Michigan
Research Focus
Dr. Timothy R. Zacharewski's lab focuses on understanding how environmental contaminants, especially a compound called TCDD, contribute to liver diseases like non-alcoholic fatty liver disease (NAFLD). The lab investigates how TCDD affects liver metabolism and causes liver damage, aiming to identify potential treatments, such as Vitamin B12 supplementation, to protect the liver from these damaging effects. This research is important because NAFLD is a growing health issue in the United States, and better understanding could lead to better treatments.
NAFLDliver diseaseTCDDAHRVitamin B12
Research Aims
3AIM 01Investigate the role of TCDD in progressing fatty liver disease.
AIM 02Test the impact of Vitamin B12 supplementation on liver health.
AIM 03Explore how specific metabolites contribute to liver toxicity.
Skills the Lab Values
RNA sequencingmetabolomicsmouse modelscell cultureChIP-seq
Output against the department
Publications169bottom 49% of dept.205th of 402
this lab
most publishedleast published
Citations10ktop 48% of dept.192nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.