University of Pittsburgh-Pittsburgh Campus · PharmacologyXie Xenobiotics Lab
Wen Xie · Pittsburgh, Pennsylvania
Research Focus
Dr. Wen Xie's lab focuses on understanding how environmental chemicals affect human health through their interactions with xenobiotic receptors. These receptors help regulate the metabolism of harmful substances in the body, potentially preventing chronic illnesses such as liver disease and neurological disorders. The research aims to uncover the mechanisms behind these interactions and find ways to mitigate their negative effects on health.
xenobiotic receptorshuman diseaseenvironmental chemicalsmetabolic syndromechronic diseasedrug metabolismtherapeutic targetsfibrosisneurological disordersgene environment interactions
Research Aims
5AIM 01Identify the role of xenobiotic receptors in disease pathogenesis.
AIM 02Explore how environmental chemicals modify human physiology.
AIM 03Investigate therapeutic targets related to xenobiotic receptors.
AIM 04Assess the interaction between environment and human health.
AIM 05Develop intervention strategies for sensitive populations.
Skills the Lab Values
genetic knockout techniquespharmacological modelingRNA sequencingcell cultureflow cytometryWestern blottingmolecular cloningbioinformaticsanimal modelstoxicology assays
Output against the department
Publications455top 12% of dept.56th of 462
this lab
most publishedleast published
Citations22ktop 16% of dept.72nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.