WMCWeill Medical College of Cornell University · Physiology
Glutamate Transport and Neurobiology Unit
Olga Boudker · New York, New York
Research Focus
Dr. Olga Boudker's lab at Weill Medical College focuses on understanding the role of glutamate transporters in neurotransmission, which is crucial for brain functions like cognition and memory. They study how these transporters interact with ions, which is essential for their operation and regulation, especially in the context of neurological disorders. By using advanced techniques like cryo-electron microscopy and single-molecule fluorescence microscopy, the lab aims to uncover the detailed mechanisms driving these transport processes.
glutamateneurotransmissionion transportbiophysicscryo-electron microscopymembrane proteinsneurobiologyprotein dynamicscognitionneurotransmitter regulation
Research Aims
5AIM 01Investigate the ion-coupling mechanisms in glutamate transporters.
AIM 02Examine the uncoupled ion permeation processes in health and disease.
AIM 03Identify the dynamic properties of transporters through advanced microscopy techniques.
AIM 04Pinpoint crucial residues and conformational states of glutamate transporters.
AIM 05Explore the evolutionary adaptations of glutamate transporters and their interaction with ions.
Skills the Lab Values
cryo-electron microscopysingle-molecule fluorescence microscopybioinformaticsmutagenesismembrane protein purificationbiochemical assaysbiophysical techniquesdata analysis in Pythoncell cultureion channel assays
Output against the department
Publications109bottom 33% of dept.193rd of 286
this lab
most publishedleast published
Citations4.5kbottom 37% of dept.180th of 286
this lab
most citedleast cited
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