University of Minnesota-Twin Cities · PhysiologyThe OsteoDiabetes Lab
Hai-Bin Ruan · Minneapolis, Minnesota
Research Focus
Dr. Hai-Bin Ruan's lab at the University of Minnesota focuses on how diabetes affects bone health, particularly exploring the role of a specific protein modification known as O-GlcNAc in bone marrow stromal cells. Their research aims to understand the mechanisms behind increased fracture risk in diabetic patients and to identify new targets for therapeutic interventions that could prevent bone loss associated with diabetes. By studying the cellular interactions and metabolic pathways involved in bone remodeling, the lab seeks to provide insights that could improve treatments for osteoporosis in individuals suffering from diabetes.
diabetesbone healthosteoporosisbone remodelingO-GlcNAc signalingbone marrow stromal cellsfracture risktherapeutic targetsdiabetic osteoporosis
Research Aims
3AIM 01Define the effects of O-GlcNAcylation on bone marrow stromal cells and bone health.
AIM 02Determine how O-GlcNAcylation is linked to BMSC dysfunction in diabetes.
AIM 03Characterize the interactions between stromal cells and myeloid cells influenced by O-GlcNAc.
Skills the Lab Values
cell culturemouse modelsflow cytometryprotein analysismolecular biology techniquesgene expression analysisbiochemical assaysdata analysis using Pythonhistological techniques
Output against the department
Publications99bottom 28% of dept.205th of 286
this lab
most publishedleast published
Citations5.3kbottom 44% of dept.160th of 286
this lab
most citedleast cited
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