Yale University · EngineeringCampbell Lab
Stuart G Campbell · New Haven, Connecticut
Research Focus
Dr. Stuart G Campbell's lab at Yale University focuses on understanding cardiac diseases, particularly Arrhythmogenic Cardiomyopathy (ACM), which can cause life-threatening heart rhythm problems. The lab develops innovative computational methods and experimental approaches to identify gene mutations responsible for these conditions, enhancing genetic screening to predict which patients might be at risk. Their work aims to uncover the complex interactions between genetic factors and external stressors, such as exercise, to improve therapies and preventative strategies for individuals with heart issues.
Arrhythmogenic Cardiomyopathysarcomeric variantsgenetic screeningcardiac diseasesbiophysical modeling
Research Aims
5AIM 01Investigate the molecular events connecting DSP mutations to heart dysfunction.
AIM 02Develop computational tools for predicting disease-causing mutations in cardiac genes.
AIM 03Test potential therapies targeting calpain vulnerability in heart tissue.
AIM 04Understand the role of exercise in exacerbating cardiac disease due to genetic mutations.
AIM 05Characterize the biophysical effects of mutations in sarcomeric proteins.
Skills the Lab Values
PCRcell culturemouse modelsbioinformaticsprotein modelinggenetic analysisCRISPRWestern blotmicroscopy
Output against the department
Publications158bottom 40% of dept.168th of 278
this lab
most publishedleast published
Citations2.3kbottom 17% of dept.230th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.