Wesleyan University · BiochemistryChromatin Dynamics Lab
Scott G Holmes · Middletown, Connecticut
Research Focus
The research lab led by Scott G Holmes at Wesleyan University focuses on understanding how specific proteins interact to regulate key processes in cells, particularly those related to gene expression and chromosome stability. By studying histones H1 and H2A.Z, the lab investigates how the balance between these proteins affects how genes are turned on or off and how chromosomes are properly segregated during cell division. This research is important for uncovering the basis of various diseases linked to chromatin dysfunction.
histone biologygene regulationchromatin structurechromosome segregationgene silencingheterochromatincell divisiontranscriptional regulationchromosomal stability
Research Aims
5AIM 01Investigate the interactions between linker histone H1 and variant histone H2A.Z.
AIM 02Determine the effects of H1 and H2A.Z balance on gene expression.
AIM 03Examine the role of histones in chromosome segregation during cell division.
AIM 04Identify how chromatin structure influences gene silencing processes.
AIM 05Explore the health implications of chromatin protein imbalances.
Skills the Lab Values
chromatin immunoprecipitation (ChIP)fluorescence microscopycell culture techniquesgenetic transcription analysischromosome ploidy assessmentWestern blottingprotein interactionsdata analysisyeast geneticsexperimental design
Output against the department
Publications36bottom 3% of dept.387th of 402
this lab
most publishedleast published
Citations1.5kbottom 5% of dept.380th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.