Rutgers University-New Brunswick · PharmacologyAntiviral Research and Development Lab
Jun Wang · New Brunswick, New Jersey
Research Focus
Dr. Jun Wang's lab at Rutgers focuses on developing innovative antiviral therapies to combat viral infections, particularly those caused by coronaviruses like SARS-CoV-2 and non-polio enteroviruses. Their research aims to identify and optimize dual inhibitors that can target both viral and host proteins critical for viral replication, ultimately leading to effective treatments. The lab is dedicated to understanding the mechanisms of these viruses and creating therapeutic options that are urgently needed in public health.
SARS-CoV-2non-polio enterovirusesantiviral developmentprotein inhibitorsdrug discovery
Research Aims
4AIM 01Develop dual inhibitors targeting viral main protease and host cathepsin L against SARS-CoV-2.
AIM 02Optimize antiviral activity and pharmacokinetic properties of 2C inhibitors for non-polio enteroviruses.
AIM 03Determine high-resolution X-ray structures of enteroviruses with inhibitors.
AIM 04Evaluate in vivo efficacy of 2C inhibitors in mouse models.
Skills the Lab Values
cell culturefluorescence resonance energy transfer (FRET)X-ray crystallographyhigh-throughput screeningmouse models