University of Pittsburgh-Pittsburgh Campus · NeuroscienceMitochondrial Bioenergetics Lab
Sarah B Berman · Pittsburgh, Pennsylvania
Research Focus
Dr. Sarah B. Berman's lab focuses on understanding how mitochondrial dysfunction affects energy metabolism in the brain, particularly in the context of Dementia with Lewy Bodies (DLB). They employ advanced brain imaging techniques to analyze the role of energy system failures in the progression of this neurodegenerative disease. Their research aims to uncover the mechanisms behind cognitive decline in DLB and identify potential therapeutic targets for neuroprotection.
mitochondrial dysfunctionbioenergeticsDementia with Lewy Bodiesbrain imagingneurodegeneration
Research Aims
4AIM 01Characterize mitochondrial respiratory dysfunction in DLB progression.
AIM 02Dissect bioenergetic pathways contributing to ATP dysregulation.
AIM 03Analyze the relationship between mitochondrial dysfunction and cognitive changes.
AIM 04Explore differences in bioenergetic dysfunction between DLB and Alzheimer's disease.
Skills the Lab Values
PET imaging31P-Magnetic Resonance Spectroscopyclinical characterizationdata analysisglycolysis assessment
Output against the department
Publications172top 44% of dept.290th of 671
this lab
most publishedleast published
Citations8.3ktop 46% of dept.309th of 671
this lab
most citedleast cited
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