University of Rochester · NeuroscienceNedergaard Lab
Maiken Nedergaard · Rochester, New York
Research Focus
Dr. Maiken Nedergaard's lab focuses on understanding how the brain clears waste and manages fluid during sleep. They investigate the connections between neural activity, blood flow, and cerebrospinal fluid movement using advanced imaging techniques, computational models, and animal studies. Their goal is to uncover how the brain's circuitry influences these processes, which can have implications for brain health and diseases.
neural circuitscerebrospinal fluidglymphatic systemblood flowsleepimaging techniquesCSF transportneurovascular couplingrodent modelscomputational modeling
Research Aims
4AIM 01Identify the neural circuit mechanisms that control cerebrospinal fluid pumping.
AIM 02Quantify the effects of neural activity on blood volume and CSF transport during sleep.
AIM 03Dissect the signaling pathways involved in neurovascular unit function as it relates to fluid movement.
AIM 04Examine how specific patterns of neural activity during sleep affect vascular dynamics.
Skills the Lab Values
optogeneticsvirus taggingimaging techniquescomputational fluid dynamics modelingparticle trackingdata analysisanimal handlingmicroscopyneuroanatomyneuroscience methodologies
Output against the department
Publications577top 9% of dept.62nd of 671
this lab
most publishedleast published
Citations93ktop 2% of dept.16th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.