Icahn School of Medicine at Mount Sinai · NeuroscienceZheng Lab
Zheng Herbert Wu · New York, New York
Research Focus
Dr. Zheng Herbert Wu's lab at the Icahn School of Medicine focuses on understanding how specific brain circuits support decision making and how the malfunctioning of these circuits can lead to psychiatric disorders like depression and addiction. By studying the premotor cortex in mice, the lab combines advanced techniques like spatial transcriptomics and in vivo imaging to identify the roles of different neuron types and their connectivity in decision-making processes. The aim is to unveil connections between genetic factors, neural behavior, and cognitive functions.
decision makingpremotor cortexpsychiatric disordersneural circuitsmolecular profiling
Research Aims
2AIM 01Determine the function of molecular cell types in the premotor cortex for decision making.
AIM 02Establish the role of afferent inputs to the premotor cortex in decision making.
Skills the Lab Values
in vivo imagingspatial transcriptomicssingle-cell RNA sequencingoptogeneticsmouse behavior assays