Duke University · Mathematics & StatisticsProtein Design and Dynamics Lab
Bruce R. Donald · Durham, North Carolina
Research Focus
Dr. Bruce R. Donald's lab at Duke University focuses on using advanced computational methods and experimental techniques to study and design proteins. The lab aims to uncover the three-dimensional structures of proteins, which are crucial for understanding diseases and designing new drugs. By developing novel algorithms and conducting in vitro and in vivo experiments, the research seeks to tackle challenges in drug resistance and create innovative therapeutics to target previously undruggable proteins.
protein structuredrug designmachine learningcomputational biologybiophysicsalgorithm developmentantibodiesprotein dynamicsin vitro studiesin vivo studies
Research Aims
5AIM 01Determine the three-dimensional structures of proteins with biomedical significance.
AIM 02Design inhibitors targeting undruggable proteins and predict resistance mutations.
AIM 03Develop free open-source software for protein structure analysis and design.
AIM 04Conduct experimental validation of computational predictions through lab experiments.
AIM 05Advance the understanding of protein-protein interactions and therapeutic antibodies.
Skills the Lab Values
computational modelingprotein engineeringin vitro techniquesin vivo experimentsalgorithm designbiophysical measurementsstructural analysisdata visualizationPython programmingmachine learning applications
Output against the department
Publications264top 43% of dept.56th of 131
this lab
most publishedleast published
Citations9.2ktop 44% of dept.58th of 131
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.