Ohio State University-Main Campus · NeuroscienceMctigue Lab
Dana M Mctigue · Columbus, Ohio
Research Focus
Dr. Dana Mctigue's lab at Ohio State University focuses on understanding how spinal cord injuries (SCI) impact liver health and metabolic functions. The research aims to uncover the mechanisms behind liver disease, specifically non-alcoholic fatty liver disease, in individuals with SCI and to find ways to improve their overall metabolic health. By studying the interactions between the nervous system and liver, the lab aims to identify potential therapies that could enhance recovery and reduce complications in spinal cord injury patients.
spinal cord injuryliver pathologymetabolic dysfunctionnon-alcoholic fatty liver diseasemetabolic syndromesympathetic nervous systemtherapeutic targets
Research Aims
5AIM 01Investigate mechanisms that lead to liver pathology after spinal cord injury.
AIM 02Identify the role of sympathetic input in liver inflammation and fat accumulation.
AIM 03Explore therapeutic targets to improve liver health in SCI individuals.
AIM 04Assess the connection between liver dysfunction and systemic metabolic disease in SCI.
AIM 05Develop strategies to enhance recovery and prevent complications in spinal cord injured patients.
Skills the Lab Values
transgenic mouse technology-omics approachesdata analysiscell cultureimmunohistochemistryWestern blotPCRsurgical proceduresmetabolic assays
Output against the department
Publications110bottom 38% of dept.410th of 671
this lab
most publishedleast published
Citations8.5ktop 45% of dept.304th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.