Cornell University · BiochemistryPugh Genomics Lab
B Franklin Pugh · Ithaca, New York
Research Focus
Dr. B Franklin Pugh's lab at Cornell University investigates how genes are regulated in yeast and humans. By starting with the simpler yeast model, they aim to understand the fundamental mechanisms of gene regulation that apply across all eukaryotic life. Their research focuses on mapping the intricate interactions between proteins and DNA, which can lead to improved diagnostics and therapies for diseases in humans.
gene regulationepigenomicsyeastChIP-exostress responsestranscription factorschromatin architecture3D mappingMediatorsSAGA
Research Aims
5AIM 01Map the epigenomic architecture of yeast in response to environmental stresses.
AIM 02Understand the molecular interactions of protein factors involved in gene regulation.
AIM 03Investigate changes in gene expression during acute and chronic stress responses.
AIM 04Define functional relationships among components of the epigenome using deletion mutations.
AIM 05Test hypotheses about conserved mechanisms in human cells parallel to those in yeast.
Skills the Lab Values
ChIP-exoDNA sequencingyeast geneticsprotein purificationcell culturetranscription analysisbiochemical assays3D genome mappingmutagenesismicroscopy
Output against the department
Publications169bottom 49% of dept.206th of 402
this lab
most publishedleast published
Citations20ktop 21% of dept.85th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.