University of Arizona · Biomedical EngineeringThe Cardiac Resilience Lab
Jil C Tardiff · Tucson, Arizona
Research Focus
Dr. Jil Tardiff's lab at the University of Arizona focuses on understanding hypertrophic cardiomyopathy (HCM), a genetic heart condition caused by mutations in the heart's contractile proteins. The lab investigates how these mutations affect heart function, particularly diastolic relaxation. By using advanced techniques, they aim to identify potential therapeutic targets for early treatment, which could significantly improve patient outcomes.
Hypertrophic CardiomyopathyCardiac SarcomereDiastolic DysfunctionMolecular RegulationDrug Discovery
Research Aims
3AIM 01Characterize specific functional domains of the cardiac thin filament.
AIM 02Determine the mechanistic effects of cTnT mutations on cardiac function.
AIM 03Design high-throughput screens for identifying small molecule modulators of diastolic performance.
Skills the Lab Values
Molecular Biology TechniquesIn Vitro AssaysAnimal ModelsFluorescence ImagingComputational Modeling
Output against the department
Publications198bottom 47% of dept.318th of 595
this lab
most publishedleast published
Citations4.3kbottom 33% of dept.400th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.