Georgetown University · Social ScienceRiggins Lab
Rebecca B Riggins · Washington, District of Columbia
Research Focus
Dr. Rebecca Riggins' lab focuses on understanding glioblastoma, one of the most aggressive brain cancers, and exploring innovative treatment strategies. The research investigates how a specific protein, ESRRB, interacts with other cellular components to influence tumor growth and mobility. By manipulating these interactions, the lab aims to develop new therapeutic approaches that could improve survival rates for glioblastoma patients.
glioblastomaESRRBalternative splicingcortactintumor motilitycancer therapyapoptosischemoresistanceunbiased screening
Research Aims
4AIM 01Investigate how SRSF6 promotes the splicing of ESRRB to increase beta2 expression.
AIM 02Test if the beta2 isoform of ESRRB inhibits glioblastoma cell motility and invasion.
AIM 03Explore how beta2 and cortactin interactions affect glioblastoma cell dynamics.
AIM 04Identify novel cytoplasmic partners of beta2 that may play a role in suppressing glioblastoma motility.
Skills the Lab Values
cell cultureRNA splicingprotein isolationWestern blotimmunoprecipitationpharmacological testingmicroscopydata analysis in cancer biologydrug screening methodologies
Output against the department
Publications241top 26% of dept.20th of 77
this lab
most publishedleast published
Citations3.3ktop 48% of dept.37th of 77
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.