MUSMedical University of South Carolina · Pharmacology
Hamann Natural Products Lab
Mark T Hamann · Charleston, South Carolina
Research Focus
The lab of Dr. Mark T Hamann focuses on the synthesis and optimization of unique natural products called aleutianamines, derived from deep-sea marine organisms. The research aims to develop effective methods for creating these alkaloids, which have potential therapeutic applications for diseases like malaria and cancer. By exploring innovative synthesis techniques, the lab seeks to address the scarcity of these natural compounds and harness their medicinal properties.
natural productssynthesis methodologiesaleutianaminemarine alkaloidstherapeutics
Research Aims
5AIM 01Develop synthesis methodologies for aleutianamines
AIM 02Investigate the mechanism of action of natural products
AIM 03Characterize starting materials for synthetic routes
AIM 04Explore biosynthetic approaches to alkaloid production
AIM 05Assess therapeutic potential of aleutianamines in disease models
Skills the Lab Values
organic synthesisnatural product extractionhigh pressure liquid chromatographystructure-activity relationship (SAR) analysiscell culture
Output against the department
Publications340top 21% of dept.97th of 462
this lab
most publishedleast published
Citations15ktop 26% of dept.122nd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.