Stanford University · BiologyStem Cell Dynamics Unit
Margaret T Fuller · Stanford, California
Research Focus
Dr. Margaret T. Fuller's lab at Stanford University studies how adult stem cells transition from proliferating to differentiating. Their research focuses on understanding the cellular mechanisms that govern this critical switch, which is important for the proper development of cells in various tissues. They use Drosophila sperm development as a model to uncover these processes, aiming to gain insights that could advance knowledge about tissue maintenance and cancer prevention.
adult stem cellsspermatogenesiscell differentiationcell proliferationRNA binding proteinsalternative splicingtranscription regulationcancerDrosophila
Research Aims
5AIM 01Investigate the molecular mechanisms that regulate the switch from cell proliferation to differentiation in adult stem cells.
AIM 02Explore the role of RNA binding proteins in timing the onset of meiotic cell cycles.
AIM 03Identify genetic and epigenetic factors that modulate cell type-specific differentiation programs.
AIM 04Understand how alternative splicing influences gene expression during cell lineage development.
AIM 05Examine the potential links between dysregulation in stem cell differentiation and cancer.
Skills the Lab Values
genome-wide transcriptomicsimmunoprecipitationcell culture techniquesDrosophila geneticsmicroscopyRNA sequencinggene expression analysisbiochemical assaysprotein analysis
Output against the department
Publications229top 27% of dept.276th of 1,033
this lab
most publishedleast published
Citations18ktop 22% of dept.228th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.