Purdue University-Main Campus · ChemistryThe Protease Project
Arun K Ghosh · West Lafayette, Indiana
Research Focus
Dr. Arun Ghosh's lab at Purdue University focuses on developing new treatments for HIV/AIDS, particularly through the design and synthesis of innovative protease inhibitors. These inhibitors aim to overcome challenges posed by drug-resistant strains of the virus and improve treatment for patients experiencing complications such as neurocognitive disorders. The lab employs advanced techniques in chemistry and biology to create more effective antiviral agents that are essential for long-term HIV management.
HIVprotease inhibitorsdrug resistanceantiviral therapyneurocognitive disorder
Research Aims
5AIM 01Design novel protease inhibitors to combat drug-resistant HIV variants.
AIM 02Synthesize and characterize new classes of antiviral compounds.
AIM 03Optimize the pharmacological properties of protease inhibitors for clinical use.
AIM 04Investigate the mechanisms of HIV-1 protease dimerization and inhibition.
AIM 05Develop strategies to improve central nervous system penetration of antiviral agents.
Skills the Lab Values
synthetic organic chemistryX-ray crystallographycell culture techniqueskinetic assaysdrug design
Output against the department
Publications802top 6% of dept.14th of 216
this lab
most publishedleast published
Citations24ktop 19% of dept.41st of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.