University of Kentucky · BiochemistryStamm Lab
Stefan Stamm · Lexington, Kentucky
Research Focus
Dr. Stefan Stamm's lab at the University of Kentucky focuses on understanding how specific modifications in RNA, particularly circular RNAs (circRNAs), contribute to Alzheimer's disease. The lab studies how these modifications might lead to the production of proteins that influence the disease process, particularly in relation to tau protein aggregation, a key feature of Alzheimer's pathology. By exploring the mechanisms behind these RNA modifications, the lab hopes to unveil new aspects of Alzheimer's disease that could lead to novel therapeutic strategies.
RNA modificationscircular RNAsAlzheimer's diseasetau aggregationprotein translation
Research Aims
3AIM 01Investigate how inosine modifications affect the translation of circRNAs involved in Alzheimer's disease.
AIM 02Analyze the relevance of RNA modification-dependent circRNA translation in human brain tissue.
AIM 03Examine the role of proteins encoded by circRNAs in promoting tau aggregation.
Skills the Lab Values
RNA sequencingpolysome preparationssiRNA techniquesdata analysisbioinformaticsmolecular cloningbiological assayscell cultureWestern blotting
Output against the department
Publications161bottom 45% of dept.219th of 402
this lab
most publishedleast published
Citations12ktop 41% of dept.164th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.