University of Texas Southwestern Medical Center · PharmacologyKidney Metabolism Research Lab
Sarah Huen · Dallas, Texas
Research Focus
Dr. Sarah Huen's lab at UT Southwestern Medical Center focuses on understanding how the kidney processes energy through metabolism, especially involving ketones. They investigate the role of specific enzymes in kidney cells that relate to kidney health and disease, particularly in the context of kidney injury and chronic kidney disease. By studying these mechanisms, the lab aims to find new ways to treat and prevent kidney-related metabolic disorders.
kidney diseaseketone metabolismmitochondrial dysfunctionchronic kidney diseaserenal ischemiametabolic homeostasisproximal tubuledistal convoluted tubulemetabolic dysregulationtherapeutic intervention
Research Aims
5AIM 01Define the roles of ketone metabolism in proximal and distal renal tubules.
AIM 02Investigate how the proximal tubule produces ketones and how they are used by neighboring cells.
AIM 03Explore the cellular mechanisms supporting mitochondrial respiration in kidney injury.
AIM 04Evaluate the impact of ketogenic gene suppression in renal health.
AIM 05Identify potential therapeutic strategies to enhance kidney metabolism.
Skills the Lab Values
cell culturemouse modelsbiochemical assaysgene knockout techniquesmitochondrial isolationmetabolite analysisflow cytometryproteomicsrenal physiologytissue histology
Output against the department
Publications43bottom 4% of dept.440th of 462
this lab
most publishedleast published
Citations3.8kbottom 29% of dept.328th of 462
this lab
most citedleast cited
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