AECAlbert Einstein College of Medicine · Biology
Oropharyngeal Cancer Research Lab
Shanye Yin · Bronx, New York
Research Focus
Dr. Shanye Yin's lab focuses on understanding how HIV and HPV interact to influence the development of oropharyngeal cancer, a type of throat cancer. By investigating the role of immune cells, particularly CD8+ T cells, in patients co-infected with these viruses, the lab aims to uncover new strategies for preventing and treating cancer in individuals living with HIV. Their research combines advanced techniques like single-cell sequencing and innovative mouse models to provide insights that could lead to improved therapies for affected patients.
HIVHPVoropharyngeal cancerCD8+ T cellssingle-cell sequencing
Research Aims
5AIM 01Investigate how HIV co-infection affects the immune cell landscape in HPV-positive oropharyngeal cancer.
AIM 02Characterize the phenotype and T cell receptors of tumor-infiltrating CD8+ T cells in the context of HIV-HPV co-infection.
AIM 03Establish a novel mouse model for studying HIV-HPV co-infection in oropharyngeal cancer.
AIM 04Explore the effects of combined antiretroviral therapy and immune checkpoint blockade on CD8+ T cell function.
AIM 05Identify potential therapeutic strategies to enhance immune responses in HPV-associated malignancies.
Skills the Lab Values
single-cell sequencingmouse modelsimmunology techniquesCD8+ T cell analysisphenotyping of immune cells
Output against the department
Publications96bottom 33% of dept.688th of 1,033
this lab
most publishedleast published
Citations1.9kbottom 12% of dept.903rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.