University of Alabama at Birmingham · Microbiology & ImmunologyHu Immunology Lab
Hui Hu · Birmingham, Alabama
Research Focus
Dr. Hui Hu's research lab at the University of Alabama at Birmingham focuses on understanding how CD4+ T cells, which are crucial for our immune responses, differentiate into various types, including memory cells. This lab studies the complex genetic and molecular processes that govern these cells' development, especially how they form during initial immune responses and later evolve into specialized types that help fight infections. Their work has significant implications for vaccine development and the treatment of immune-related diseases.
CD4+ T cellsT follicular helper cellsimmune responseT cell differentiationmemory T cellsvaccine developmentautoimmune diseasescellular immunityhumoral immunity
Research Aims
5AIM 01Identify novel genes and pathways involved in CD4+ T cell differentiation.
AIM 02Dissect mechanisms of pre-Tfh to GC-Tfh differentiation.
AIM 03Investigate the generation of diversified memory CD4+ T cells.
AIM 04Explore the effects of CXCR5 expression on T cell responses.
AIM 05Understand implications for vaccine development against infectious diseases.
Skills the Lab Values
RNA sequencingATAC-seqsingle cell RNA-seqmouse modelsfate-mapping techniquesflow cytometrycell cultureimmunological assaysprotein analysis
Output against the department
Publications435top 7% of dept.35th of 486
this lab
most publishedleast published
Citations15ktop 25% of dept.122nd of 486
this lab
most citedleast cited
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