Washington University in St Louis · BiochemistryCardiovascular and Neurobiology Unit
Benjamin A Garcia · Saint Louis, Missouri
Research Focus
Dr. Benjamin A Garcia's lab at Washington University focuses on understanding complex biological processes related to cardiovascular health and neurological development using cutting-edge chemical biology approaches. The lab investigates the role of specific protein modifications in heart development and disease, as well as how epigenetic mechanisms influence neurological disorders. By employing advanced mass spectrometry and innovative research techniques, they aim to uncover new therapeutic strategies and improve our understanding of critical cellular functions.
protein arginylationmass spectrometryepigeneticsneurodevelopmental disorderschemical biologyRNA modificationscardiovascular healthprotein degradationCRISPR
Research Aims
5AIM 01Investigate the role of protein arginylation in cardiovascular development.
AIM 02Profile arginylation sites in cardiac cells and tissues using chemical proteomics.
AIM 03Understand the effects of neurohistone mutations on epigenetic mechanisms.
AIM 04Develop high-throughput methods for studying RNA modifications.
AIM 05Explore therapeutic applications of protein arginylation in cardiovascular disease.
Skills the Lab Values
mass spectrometryCRISPRcell cultureprotein analysisnext-generation sequencingbiochemical assaysdata analysisRNA extractionmicroscopy
Output against the department
Publications578top 7% of dept.29th of 402
this lab
most publishedleast published
Citations45ktop 5% of dept.22nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.