Yale University · Microbiology & ImmunologyHematopoietic Development and Signaling Laboratory
Joao Pereira · New Haven, Connecticut
Research Focus
Dr. Joao Pereira's research lab at Yale University focuses on understanding how blood cells, particularly immune cells, develop from stem cells in the bone marrow. The lab investigates the complex signaling mechanisms that regulate the balance between cell dormancy and activity, which are crucial for maintaining a healthy immune system. Through a combination of advanced molecular techniques and imaging methods, the team's work aims to uncover new insights into immune disorders and potential therapeutic targets for diseases like cancer.
hematopoietic stem cellsimmune systemB lymphocyte developmentstem cell homeostasisGPCR signalingcell migration2-photon microscopyin situ confocal microscopygene deletionlymphoproliferative diseases
Research Aims
4AIM 01Investigate how GPR56 and GPR97 control hematopoietic stem cell quiescence, self-renewal, and survival.
AIM 02Visualize the impact of GPCRs on hematopoietic stem cell localization within the niche.
AIM 03Study the signal transduction pathways regulated by GPR56 and GPR97 using selective gene deletion.
AIM 04Understand the functional mechanisms underlying hematopoietic stem cell homeostasis and differentiation.
Skills the Lab Values
PCRcell culturegene deletion techniquesintravital 2-photon microscopyconfocal microscopyRNA isolationflow cytometryWestern blotanimal modelsbioinformatics
Output against the department
Publications265top 21% of dept.99th of 486
this lab
most publishedleast published
Citations22ktop 17% of dept.81st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.