UCUniversity of Cincinnati-Main Campus · Biology
Stress and Neuronal Health Lab
Eric S Wohleb · Cincinnati, Ohio
Research Focus
Dr. Eric S Wohleb's lab at the University of Cincinnati investigates how chronic stress impacts the brain, particularly focusing on how stress causes changes in neurons that can lead to mental health disorders like PTSD and depression. The research looks at DNA damage in stressed neurons and how it alters gene activity and neuron structure. By understanding these processes, the lab aims to find new ways to treat stress-related cognitive issues.
chronic stressDNA double strand breakschromatin structureneuron functionmental health disordersgene expressionneuronal remodelingPTSDmajor depressive disorder
Research Aims
5AIM 01Map genome-wide sites of DNA double strand breaks caused by chronic stress.
AIM 02Investigate how DNA breaks affect gene activity in stress-activated neurons.
AIM 03Determine the impact of chromatin architecture changes on neuronal remodeling.
AIM 04Examine how recurrent DNA breaks regulate gene expression patterns during chronic stress.
AIM 05Uncover potential therapeutic strategies for managing psychiatric disorders related to chronic stress.
Skills the Lab Values
DNA sequencingchromatin conformation capture (3C)Western blotconfocal microscopycell culturemouse modelsgene expression analysisbiochemical assaysbioinformatics
Output against the department
Publications113bottom 40% of dept.621st of 1,033
this lab
most publishedleast published
Citations8.4ktop 45% of dept.469th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.