Rutgers University-New Brunswick · Microbiology & ImmunologyChang Immunology Lab
Theresa L Chang · New Brunswick, New Jersey
Research Focus
Dr. Theresa L. Chang's lab at Rutgers University focuses on understanding how sex differences affect immune responses in people living with HIV/AIDS. They investigate how these differences impact disease progression and the persistence of the virus in the body, with the aim of improving treatment strategies. By studying a specialized animal model that mimics human HIV infection, the lab aims to explore the role of estrogen in immune regulation and viral persistence.
HIVsex differencesimmune activationviral persistencepersonalized therapyanimal modelsestrogenintestinal immune responsechronic disease
Research Aims
5AIM 01Investigate sex-specific immune parameters associated with HIV viral persistence.
AIM 02Explore the effects of estrogen on immune responses in HIV-infected individuals.
AIM 03Develop a reliable animal model to study sex differences in HIV pathogenesis.
AIM 04Assess the contribution of immune dysregulation to disease progression based on sex.
AIM 05Identify personalized therapeutic targets to improve HIV treatment outcomes.
Skills the Lab Values
cell culturerhesus macaque modelsflow cytometryWestern blotRNA sequencingimmunoassaysbiostatisticsmolecular cloninggene expression analysis
Output against the department
Publications92bottom 31% of dept.331st of 486
this lab
most publishedleast published
Citations3.1kbottom 22% of dept.381st of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.