Indiana University-Purdue University-Indianapolis · BiologyThe Heart Signal Lab
Steven S Welc · Indianapolis, Indiana
Research Focus
Dr. Steven S Welc's lab focuses on understanding the mechanisms behind cardiac disease in patients with Duchenne muscular dystrophy (DMD). They investigate how fibroblasts, which are cells that help maintain the structure of heart tissue, produce specific signals that can worsen heart problems associated with DMD. The goal is to find new ways to target these signals for potential therapies to improve heart function and overall health for affected individuals.
Duchenne muscular dystrophyfibroblastsFGF23cardiac myocytesheart diseasepathologic remodelingtherapeuticsfibrosissignal transduction
Research Aims
2AIM 01Identify if fibroblasts produce FGF23 that promotes heart issues in DMD.
AIM 02Determine the effects of FGFR4 activation in heart cells related to DMD.
Skills the Lab Values
cell cultureex vivo experimentsgenetic mouse modelsconditional genetic approachesgain-of-function studiesloss-of-function studiesimmunohistochemistryRNA analysiselectrophysiology
Output against the department
Publications44bottom 9% of dept.937th of 1,033
this lab
most publishedleast published
Citations1.1kbottom 6% of dept.974th of 1,033
this lab
most citedleast cited
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